Brazilian version of the Addenbrooke Cognitive Examination-revised in the diagnosis of mild Alzheimer disease.
نویسندگان
چکیده
OBJECTIVE To investigate the accuracy of the Brazilian version of the Addenbrooke Cognitive Examination-revised (ACE-R) in the diagnosis of mild Alzheimer disease (AD). BACKGROUND The ACE-R is an accurate and brief cognitive battery for the detection of mild dementia, especially for the discrimination between AD and frontotemporal dementia. METHODS The battery was administered to 31 patients with mild AD and 62 age-matched and education-matched cognitively healthy controls. Both groups were selected using the Dementia Rating Scale and were submitted to the ACE-R. Depression was ruled out in both groups by the Cornell Scale for Depression in Dementia. The performance of patients and controls in the ACE-R was compared and receiver operator characteristic curve analysis was undertaken to ascertain the accuracy of the instrument for the diagnosis of mild AD. RESULTS The mean scores at the ACE-R were 63.10+/-10.22 points for patients with AD and 83.63+/-7.90 points for controls. The cut-off score <78 yielded high diagnostic accuracy (receiver operator characteristic area under the curve=0.947), with 100% sensitivity, 82.26% specificity, 73.8% positive predictive value, and 100% negative predictive value. CONCLUSIONS The Brazilian version of the ACE-R displayed high diagnostic accuracy for the identification of mild AD in the studied sample.
منابع مشابه
Author's response to reviews Title:Differential diagnosis of depression and Alzheimer's disease with the Addenbrooke Cognitive Examination-Revised Authors:
متن کامل
Cognitive Rehabilitation An Effective Intervention to Decrease the Cognitive Deficits in Older Adults With Alzheimer Disease
Objectives: The aim of present study was to investigate the effect of cognitive rehabilitation, a new and non-pharmacological approach to reduce memory and other cognitive deficits in Alzheimer's disease. Methods & Materials: This study was a quasi-experimental research, in singlesubject study-with control group- and based on an A-B design. That was conducted in two groups of control and exp...
متن کاملEffect of Mild Cognitive Impairment and Alzheimer Disease on Auditory Steady-State Responses
Introduction: Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods: In this study, the thresholds of...
متن کاملP 62: Markers of Neuroinflammation Related to Alzheimer\'s Disease Pathology in the Elderly
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...
متن کاملBrazilian adaptation of the Addenbrooke’s Cognitive Examination-Revised (ACE-R)
The Addenbrooke's Cognitive Examination-Revised (ACE-R) is a highly sensitive and specific tool for the detection of mild dementia. It is particularly useful in differentiating Alzheimer's disease from frontotemporal dementia. While the first version of the test battery has been adapted in many countries, its revised version has not, probably because it was published very recently. Objective ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
دوره 23 1 شماره
صفحات -
تاریخ انتشار 2010